Ameli, open Knowledge for Latin America and the Global South (AmeliCA) is an initiative set up by the United Nations Educational, Scientific and Cultural Organization (UNESCO), the Latin American Council of Social Sciences ( CLACSO ), the network of scientific journals of Latin America and the Caribbean, Spain and Portugal (REDALYC), the Autonomous University of the State of Mexico (UAEM), the University of Antioquia (UdeA), the National University of La Plata (UNLP) and the University of Panama (UP). This is a new strategy configuration, in response to the international, regional, national and institutional context, which seeks a collaborative, sustainable, protected and non-commercial open access solution for Latin America and the Global South.